Nigsch, Florian: search on Z-Library

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1

Evidence-Based and Quantitative Prioritization of Tool Compounds in Phenotypic Drug Discovery

Wang, Yuan, Cornett, Allen, King, Fred J., Mao, Yi, Nigsch, Florian, Paris, C. Gregory, McAllister, Gregory, Jenkins, Jeremy L.

Journal:

Cell Chemical Biology

Year:

2016

Language:

english

File:

PDF, 3.00 MB

english, 2016

2

Rethinking Molecular Similarity: Comparing Compounds on the Basis of Biological Activity

Petrone, Paula M., Simms, Benjamin, Nigsch, Florian, Lounkine, Eugen, Kutchukian, Peter, Cornett, Allen, Deng, Zhan, Davies, John W., Jenkins, Jeremy L., Glick, Meir

Journal:

ACS Chemical Biology

Year:

2012

Language:

english

File:

PDF, 4.21 MB

english, 2012

3

Determination of minimal transcriptional signatures of compounds for target prediction

Nigsch, Florian, Hutz, Janna, Cornett, Ben, Selinger, Douglas W, McAllister, Gregory, Bandyopadhyay, Somnath, Loureiro, Joseph, Jenkins, Jeremy L

Journal:

EURASIP Journal on Bioinformatics and Systems Biology

Year:

2012

Language:

english

File:

PDF, 226 KB

english, 2012

4

Classifying Large Chemical Data Sets: Using A Regularized Potential Function Method

Mussa, Hamse Y., Hawizy, Lezan, Nigsch, Florian, Glen, Robert C.

Journal:

Journal of Chemical Information and Modeling

Year:

2011

Language:

english

File:

PDF, 4.61 MB

english, 2011

5

Multidimensional pooled shRNA screens in human THP-1 cells identify candidate modulators of macrophage polarization

Surdziel, Ewa, Clay, Ieuan, Nigsch, Florian, Thiemeyer, Anke, Allard, Cyril, Hoffman, Gregory, Reece-Hoyes, John S., Phadke, Tanushree, Gambert, Romain, Keller, Caroline Gubser, Ludwig, Marie-Gabriell

Journal:

Year:

2017

Language:

english

File:

PDF, 3.03 MB

english, 2017

6

A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi

Voorberg-van der Wel, Annemarie, Roma, Guglielmo, Gupta, Devendra Kumar, Schuierer, Sven, Nigsch, Florian, Carbone, Walter, Zeeman, Anne-Marie, Lee, Boon Heng, Hofman, Sam O, Faber, Bart W, Knehr, Jud

Journal:

Year:

2017

Language:

english

File:

PDF, 2.82 MB

english, 2017

7

Ligand-Target Prediction Using Winnow and Naive Bayesian Algorithms and the Implications of Overall Performance Statistics

Nigsch, Florian, Bender, Andreas, Jenkins, Jeremy L., Mitchell, John B. O.

Journal:

Journal of Chemical Information and Modeling

Year:

2008

Language:

english

File:

PDF, 1.92 MB

english, 2008

8

How To Winnow Actives from Inactives: Introducing Molecular Orthogonal Sparse Bigrams (MOSBs) and Multiclass Winnow

Nigsch, Florian, Mitchell, John B. O.

Journal:

Journal of Chemical Information and Modeling

Year:

2008

Language:

english

File:

PDF, 255 KB

english, 2008

9

The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

Planas-Paz, Lara, Orsini, Vanessa, Boulter, Luke, Calabrese, Diego, Pikiolek, Monika, Nigsch, Florian, Xie, Yang, Roma, Guglielmo, Donovan, Adriana, Marti, Patricia, Beckmann, Nicolau, Dill, Michael T

Journal:

Nature Cell Biology

Year:

2016

Language:

english

File:

PDF, 3.97 MB

english, 2016

10

IRF2 is a master regulator of human keratinocyte stem cell fate

Mercado, Nicolas, Schutzius, Gabi, Kolter, Christian, Estoppey, David, Bergling, Sebastian, Roma, Guglielmo, Gubser Keller, Caroline, Nigsch, Florian, Salathe, Adrian, Terranova, Remi, Reece-Hoyes, Jo

Journal:

Nature Communications

Year:

2019

Language:

english

File:

PDF, 7.82 MB

english, 2019

11

Total Synthesis of (+)-Crocacin D (I).

Luiz C. Dias, Luciana G. de Oliveira, Janaina D. Vilcachagua, Florian Nigsch

Journal:

Year:

2005

File:

PDF, 11 KB

2005

12

Predicting the mechanism of phospholipidosis

Robert Lowe, Hamse Y Mussa, Florian Nigsch, Robert C Glen, John BO Mitchell

Journal:

Journal of Cheminformatics

Year:

2012

Language:

english

File:

PDF, 751 KB

english, 2012

13

In vitro models for processes involved in intestinal absorption

Nigsch, Florian, Klaffke, Werner, Miret, Silvia

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2007

Language:

english

File:

PDF, 301 KB

english, 2007

14

Why Are Some Properties More Difficult To Predict than Others? A Study of QSPR Models of Solubility, Melting Point, and Log P

Hughes, Laura D., Palmer, David S., Nigsch, Florian, Mitchell, John B. O.

Journal:

Journal of Chemical Information and Modeling

Year:

2008

Language:

english

File:

PDF, 437 KB

english, 2008

15

Recent trends and observations in the design of high-quality screening collections

Renner, Steffen, Popov, Maxim, Schuffenhauer, Ansgar, Roth, Hans-Joerg, Breitenstein, Werner, Marzinzik, Andreas, Lewis, Ian, Krastel, Philipp, Nigsch, Florian, Jenkins, Jeremy, Jacoby, Edgar

Journal:

Future Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1022 KB

english, 2011

16

Corrigendum: The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

Planas-Paz, Lara, Orsini, Vanessa, Boulter, Luke, Calabrese, Diego, Pikiolek, Monika, Nigsch, Florian, Xie, Yang, Roma, Guglielmo, Donovan, Adriana, Marti, Patricia, Beckmann, Nicolau, Dill, Michael T

Journal:

Nature Cell Biology

Year:

2016

Language:

english

File:

PDF, 147 KB

english, 2016

17

Activity-Aware Clustering of High Throughput Screening Data and Elucidation of Orthogonal Structure–Activity Relationships

Lounkine, Eugen, Nigsch, Florian, Jenkins, Jeremy L., Glick, Meir

Journal:

Journal of Chemical Information and Modeling

Year:

2011

Language:

english

File:

PDF, 1.07 MB

english, 2011

18

Computational toxicology: an overview of the sources of data and of modelling methods

Nigsch, Florian, Macaluso, NJ Maximilan, Mitchell, John BO, Zmuidinavicius, Donatas

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2009

Language:

english

File:

PDF, 943 KB

english, 2009

19

Analysis of Iterative Screening with Stepwise Compound Selection Based on Novartis in-house HTS Data

Paricharak, Shardul, IJzerman, Adriaan P., Bender, Andreas, Nigsch, Florian

Journal:

ACS Chemical Biology

Year:

2016

Language:

english

File:

PDF, 2.57 MB

english, 2016

20

Genome-wide CRISPR screen for PARKIN regulators reveals transcriptional repression as a determinant of mitophagy

Potting, Christoph, Crochemore, Christophe, Moretti, Francesca, Nigsch, Florian, Schmidt, Isabel, Manneville, Carole, Carbone, Walter, Knehr, Judith, DeJesus, Rowena, Lindeman, Alicia, Maher, Rob, Rus

Journal:

Proceedings of the National Academy of Sciences

Year:

2017

Language:

english

File:

PDF, 1.54 MB

english, 2017

21

Simultaneous feature selection and parameter optimisation using an artificial ant colony: case study of melting point prediction

Noel M O'Boyle, David S Palmer, Florian Nigsch, John BO Mitchell

Journal:

Chemistry Central Journal

Year:

2008

Language:

english

File:

PDF, 2.49 MB

english, 2008

22

A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space

Sai Chetan K. Sukuru, Florian Nigsch, Jean Quancard, Martin Renatus, Rajiv Chopra, Natasja Brooijmans, Dmitri Mikhailov, Zhan Deng, Allen Cornett, Jeremy L. Jenkins, Ulrich Hommel, John W. Davies, Mei

Journal:

Protein Science

Year:

2010

Language:

english

File:

PDF, 1.19 MB

english, 2010

23

Computational methods for early predictive safety assessment from biological and chemical data

Nigsch, Florian, Lounkine, Eugen, McCarren, Patrick, Cornett, Ben, Glick, Meir, Azzaoui, Kamal, Urban, Laszlo, Marc, Philippe, Müller, Arne, Hahne, Florian

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2011

Language:

english

File:

PDF, 893 KB

english, 2011

24

A novel hybrid ultrafast shape descriptor method for use in virtual screening

Edward O Cannon, Florian Nigsch, John BO Mitchell

Journal:

Chemistry Central Journal

Year:

2008

Language:

english

File:

PDF, 247 KB

english, 2008

25

Screening of Intestinal Crypt Organoids

Ley, Svenja, Galuba, Olaf, Salathe, Adrian, Melin, Nicolas, Aebi, Alexandra, Pikiolek, Monika, Knehr, Judith, Carbone, Walter, Beibel, Martin, Nigsch, Florian, Roma, Guglielmo, d’Ario, Giovanni, Kirkl

Journal:

Year:

2017

Language:

english

File:

PDF, 2.50 MB

english, 2017

26

Toxicological relationships between proteins obtained from protein target predictions of large toxicity databases

Florian Nigsch, John B.O. Mitchell

Journal:

Toxicology and Applied Pharmacology

Year:

2008

Language:

english

File:

PDF, 865 KB

english, 2008

27

Total Synthesis of (+)-Crocacin D †

Dias, Luiz C., de Oliveira, Luciana G., Vilcachagua, Janaína D., Nigsch, Florian

Journal:

Journal of Organic Chemistry

Year:

2005

Language:

english

File:

PDF, 276 KB

english, 2005

28

Melting Point Prediction Employing k-Nearest Neighbor Algorithms and Genetic Parameter Optimization

Nigsch, Florian, Bender, Andreas, van Buuren, Bernd, Tissen, Jos, Nigsch, Eduard, Mitchell, John B. O.

Journal:

Journal of Chemical Information and Modeling

Year:

2006

Language:

english

File:

PDF, 261 KB

english, 2006

29

Data-driven Derivation of an “Informer Compound Set” for Improved Selection of Active Compounds in High-Throughput Screening

Paricharak, Shardul, IJzerman, Adriaan P., Jenkins, Jeremy L., Bender, Andreas, Nigsch, Florian

Journal:

Journal of Chemical Information and Modeling

Year:

2016

Language:

english

File:

PDF, 1.87 MB

english, 2016

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